|
KMID : 1188320130070020246
|
|
Gut and Liver
2013 Volume.7 No. 2 p.246 ~ p.251
|
|
|
Transcatheter Arterial Chemotherapy with Miriplatin for Hepatocellular Carcinoma Patients with Chronic Renal Failure: Report of Three Cases
|
|
Norihiro Imai
Kenji Ikeda
Yuya Seko
Yusuke Kawamura
Hitomi Sezaki
Tetsuya Hosaka
Norio Akuta
Masahiro Kobayashi
Satoshi Saitoh
Fumitaka Suzuki
Yoshiyuki Suzuki
Yasuji Arase
Hiromitsu Kumada
|
|
|
Abstract
|
|
|
|
Miriplatin is a novel lipophilic platinum complex that was developed to treat hepatocellular carcinoma (HCC). Although HCC patients frequently have coexisting chronic renal failure, little prospective data are available regarding the clinical toxicity of chemotherapeutic agents used to treat HCC patients with chronic renal failure. In a phase II study, the plasma concentration of total platinum in patients who received miriplatin was very low, and no severe renal toxicity caused by miriplatin injection was reported. Here, we present three cases of HCC with stage 4 chronic renal failure who received transcatheter arterial chemotherapy with miriplatin. All cases were male, ages 72, 84, and 83 years, and had serum creatinine levels of 2.3, 1.6, and 1.9 mg/dL, respectively. Their estimated glomerular filtration rates were 21.9, 20.3, and 22.2 mL/min, respectively. All cases were treated for unresectable HCC with transcatheter arterial chemotherapy with miriplatin. No serious adverse events were observed, and serum creatinine levels did not elevate, even in the patient who experienced renal failure caused by cisplatin administration. These results might suggest that transcatheter arterial chemotherapy with miriplatin can be safely used in HCC patients with chronic renal failure.
|
|
|
KEYWORD
|
|
|
Miriplatin, Chronic renal failure, Hepatocellular carcinoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|